A wireless keyboard and mouse is a pretty cool thing, but sometimes these devices can get a little cranky. There’s not too many things worse than having your keyboard or mouse misbehave when trying to meet a deadline on a project. I generally recommend keeping a wired keyboard and mouse on hand just in case.
If you do experience connectivity issues, here are a few things to try/consider:
1. Start here: Apple Support Document on Troubleshooting Wireless Keyboard and Mouse issues
2. Make sure your computer’s software is up to date. Simply run Software Update under the Apple Menu.
3. The expected 10.5.7 update should be out soon. With some of it’s reported fixes being in the area of Bluetooth reliability, hopefully this update will solve any Bluetooth connectivity issues.
4. Some people are experiencing a loss of connectivity after waking their computer from sleep. Try going to Apple Menu > System Preferences > Energy Saver and setting your computer’s sleep option to “Never”. If Bluetooth is having a connectivity issue after waking from sleep, this would help (setting the display to go to sleep is fine). It’s a workaround, not a fix, but would get you by until the release of 10.5.7, if the 10.5.7 update does indeed provide the expected reliability enhancements.

For what it’s worth, I’m not a big fan of Sleep anyway. Although to sleep or not to sleep is a topic of much debate, I like to have my machines respond immediately (among other reasons).
Have any thoughts or tips on Bluetooth connectivity? Leave a comment. You just might help someone out!!